Modeling HCV kinetics under therapy using PK and PD information

(PK/PD) Modeling of Anti-Neoplastic Agents

In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis

BACKGROUND Haemophilus parasuis (H. parasuis) causes Glässer's disease and multisystem infectious disease. It is one of the major causes of nursery mortality in swine herds. Cefquinome (CEQ) is proposed for the treatment of pigs against respiratory tract infection. However, few studies have investigated the PK/PD characteristics and PK/PD cutoff of this drug against H. parasuis. RESULTS A tot...

Stochastic PK/PD Modelling

This thesis describes the development of a software prototype implemented in Matlab for non-linear mixed effects modelling based on stochastic differential equations (SDEs). The setup aims at modelling measurements originating from more than one individual and it represents a powerful way of modelling systems with complicated and partially unknown dynamics. The incorporation of SDEs enables the...

Population PK/PD Analysis

Pharmacokinetics and pharmacodynamics are divisions of pharmacology that study the action of the body on the drug and the action of the drug on the body, respectively. They complete dose titration studies aimed to select rational dosage regimens. The classical pharmacokinetic (PK)/pharmacodynamic (PD) studies are experimental. They are usually performed on healthy volunteers or highly selected ...

Covariate Modeling in Population PK/PD Models: an Open Problem

In the last decade PK/PD modeling has reached a new level of maturity, acceptance, and influence and is increasingly considered a central technology for improving both drug development and clinical therapy. Pharmacological effects can be measured at the biochemical, cellular, organ, individual, or clinical level. The integration of diverse pharmacological effects into a coherent picture of drug...